Exfoliation at home will help to make the wrinkles look less deep. Try Microdermabrasion with Crushed Diamonds three times a week. Then use StemCellution Serum, it will help to build the skin, but also works as an instant filler.
At the clinic a three-step approach works well to eliminate the lines; Injections of a filler like Juvéderm or Restylane can fill them in. A very small amount of Botox, injected into the sides of the mouth, can prevent the kind of puckering that helps to cause them. Finally, one treatment with a fractional CO2 laser can get rid of them for more than ten years but expect downtime of around three days to a week of redness and swelling.